Medicinal Characteristics of Withania somnifera L. in Colorectal Cancer Management

نویسندگان

چکیده

Research into tumorigenic pathways can aid in the development of more efficient cancer therapies and provide insight physiological regulatory mechanisms employed by rapidly proliferating cells. Due to severe side effects chemotherapeutic medications, plant chemicals their analogues are now explored frequently for treatment prevention colorectal (CRC), opening stage new phytotherapeutic strategies that considered effective safe substitutes. Our study aimed evaluate medicinal properties Withania somnifera L. its safety applications CRC management. Important databases were rigorously searched relevant literature, only 68 full-text publications matched inclusion requirements from a massive collection 6421 titles abstracts. W. contains high concentration active plant-based compounds. The pharmacological activity our has been demonstrated exert antiproliferation, upregulation apoptosis, decrease oxidative stress, downregulation cyclooxygenase-2 (COX-2), induction targeted cytotoxic on cancerous cells, exertion both antiangiogenesis antimigratory effects. We advise further research before recommending clinical use identify optimal concentrations required elicit beneficial management humans, singly or combination.

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ژورنال

عنوان ژورنال: Pharmaceuticals

سال: 2023

ISSN: ['1424-8247']

DOI: https://doi.org/10.3390/ph16070915